refractory epilepsy prevalence

Keywords: Neurology.  |  Clipboard, Search History, and several other advanced features are temporarily unavailable. 2007;48 Suppl 1:14-8. doi: 10.1111/j.1528-1167.2007.00994.x. Refractory epilepsy displays three similar categories. eCollection 2020 Sep. Alcala-Zermeno JL, Gregg NM, Van Gompel JJ, Stead M, Worrell GA, Lundstrom BN. The objective of this systematic review is to evaluate the consistency between definitions of DRE in the literature and the official definition in the International League Against Epilepsy (ILAE) guidelines, and to estimate the incidence, prevalence, and risk factors for DRE. eCollection 2020. Age at onset, symptomatic epilepsy, abnormal neuroimaging findings, abnormal electroencephalography results, history of mental retardation, neuropsychiatric disorders, febrile seizure, and status epilepticus increased risk for DRE. 2018 Sep 1:1-15. doi: 10.3171/2018.3.JNS171722. These numbers vary depending on when the studies were done, who was included, and a host of other factors. Epidemiological data indicate that 20-40% of the patients with newly diagnosed epilepsy will become refractory to treatment. Zavala-Tecuapetla C, Cuellar-Herrera M, Luna-Munguia H. Int J Mol Sci. 2020 Aug 3;3(3):245-255. doi: 10.1002/ame2.12131. Epidemiological data indicate that 20-40% of the patients with newly diagnosed epilepsy will become refractory to treatment. Epilepsy Prevalence in the United States. An estimation of global volume of surgically treatable epilepsy based on a systematic review and meta-analysis of epilepsy. The definition of DRE varied widely across studies, with only 12% meeting the requirements of the ILAE definition. The incidence of refractory epilepsy remains high despite the influx of many new antiepileptic drugs (AEDs) over the past 10 years. Please enable it to take advantage of the complete set of features! USA.gov. Random-effect model meta-analyses were used to generate pooled estimates of prevalence or incidence and pooled odds ratios of the association with risk factors. P38 Regulates Kainic Acid-Induced Seizure and Neuronal Firing via Kv4.2 Phosphorylation. They may worry alot about when their next seizure will come. 2019 Jul;98(30):e16402. 2020 May 20;5(2):263-273. doi: 10.1002/epi4.12397. This site needs JavaScript to work properly. Eur J Paediatr Neurol. In 2015, 1.2% of the US population had active epilepsy (95% CI* = 1.1-1.4). JME is a heterogenous disorder in which the prognoses have not been entirely clear. NLM The potential of pharmacogenetics in the treatment of epilepsy. Epilepsy Res. There are limited high-quality data available on DRE. Charupanit K, Sen-Gupta I, Lin JJ, Lopour BA. 2020 Aug 18;21(16):5921. doi: 10.3390/ijms21165921. Prevalence and Incidence of Drug-Resistant Mesial Temporal Lobe Epilepsy in the United States. This prevalence of refractoriness affecting one-third of people with … Wiley Periodicals, Inc. © 2018 International League Against Epilepsy. Pharmacokinetic, pharmacodynamic, and neurochemical investigations of lamotrigine-pentylenetetrazole kindled mice to ascertain it as a reliable model for clinical drug-resistant epilepsy. 2014 Sep;108(7):1253-62. doi: 10.1016/j.eplepsyres.2014.05.005. Prevalence of drug resistant epilepsy in adults with epilepsy attending a neurology clinic of a tertiary referral hospital in Singapore. Orozco-Hernández JP, Quintero-Moreno JF, Marín-Medina DS, Valencia-Vásquez A, Villada HC, Lizcano A, Martínez JW. Eur Neurol. Telemedicine, drug-resistant epilepsy, and ketogenic dietary therapies: A patient survey of a pediatric remote-care program during the COVID-19 pandemic. Altered expression of parvalbumin immunoreactivity in rat main olfactory bulb following pilocarpine-induced status epilepticus. Get the latest public health information from CDC: https://www.coronavirus.gov. 1,2 Think of a school with 1,000 students—this means about 6 of them could have epilepsy. drug resistant; epidemiology; epilepsy; frequency; review; risk. Basic Clin Neurosci. Get the latest public health information from CDC: https://www.coronavirus.gov. Get the latest research from NIH: https://www.nih.gov/coronavirus. One chart review study by Smith and colleagues in England found that 13% of patients referred for refractory epilepsy did not have epilepsy. Quantifying the response to antiepileptic drugs: effect of past treatment history. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. NIH Plasticity of antiepileptic drug targets. MEDLINE and EMBASE were searched for observational studies of DRE published between January 1980 and July 2015. Lack of consistency in definitions limits the ability to obtain robust estimates on the burden of DRE.  |  Epilepsy Behav. eCollection 2020 Jun. Epilepsia. HHS World Neurosurg. Insights into Potential Targets for Therapeutic Intervention in Epilepsy. 2017 Mar;99:662-666. doi: 10.1016/j.wneu.2016.12.074. Significance: Treatment resistance is, therefore, a multifaceted phenomenon. Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms. Environmental factors, such as trauma and prior drug exposure, and genetic factors that predetermine the rate of absorption, metabolism, and uptake of a drug by target tissue may also uniquely impact an individual and influence their response to AED therapy. An incorrect diagnosis of epilepsy, going to the wrong house, is more common than most people might think. Amygdala Low-Frequency Stimulation Reduces Pathological Phase-Amplitude Coupling in the Pilocarpine Model of Epilepsy. Cortical and thalamic electrode implant followed by temporary continuous subthreshold stimulation yields long-term seizure freedom: A case report. Epub 2020 Oct 3. 2020 May-Jun;11(3):333-347. doi: 10.32598/bcn.11.2.1713.1. If your doctor thinks you have refractoryepilepsy, he or she may suggest that you visit a medical center thatspecializes in epilepsy. 1 Stevelink et al found an unexpectedly high prevalence of refractoriness in JME (35%) based on all seizure types (i.e., absence, myoclonic, and generalized tonic-clonic seizures). The definitions of DRE in these studies were compared with the definition in the ILAE guidelines. According to the latest estimates, about 0.6% of children aged 0-17 years have active epilepsy. In 2015, 1.2% of the total US population had active epilepsy.  |  2008 Jan 1;70(1):54-65. doi: 10.1212/01.wnl.0000286959.22040.6e. COVID-19 is an emerging, rapidly evolving situation. Epub 2016 Dec 27. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Online ahead of print. 2020 Nov;112:107493. doi: 10.1016/j.yebeh.2020.107493. NCI CPTC Antibody Characterization Program. The pooled prevalence proportion of DRE among epilepsy patients was 0.30 (95% confidence interval [CI] 0.19-0.42), and the pooled incidence proportion was 0.15 (95% CI 0.11-0.19). 2006 Mar;10(2):57-65. doi: 10.1016/j.ejpn.2005.11.009. 2020 Nov 13;21(22):8573. doi: 10.3390/ijms21228573. NIH COVID-19 is an emerging, rapidly evolving situation. Xue-Ping W, Hai-Jiao W, Li-Na Z, Xu D, Ling L. Medicine (Baltimore). 2020 Nov 13;10(11):856. doi: 10.3390/brainsci10110856. The definition of drug-resistant epilepsy (DRE) affects case identification and treatment, and impacts prevalence or incidence estimates and health burden estimation in epidemiology.  |  The number of people with epilepsy, using prevalence numbers, ranges from 1.3 million to 2.8 million (or 5 to 8.4 for every 1,000 people). Epilepsia. Clipboard, Search History, and several other advanced features are temporarily unavailable. Objective: Detection of anomalous high-frequency events in human intracranial EEG. Methods: Mihály I, Orbán-Kis K, Gáll Z, Berki ÁJ, Bod RB, Szilágyi T. Brain Sci. 2009;62(2):65-71. doi: 10.1159/000222775. Epub 2009 Jun 12. Multivariable prediction model of drug resistance in adult patients with generalized epilepsy from Colombia: A case-control study. This site needs JavaScript to work properly.  |  Factors that may be used to predict whether or not a patient will respond favorably to AED therapy include the type of epilepsy, underlying syndrome, etiology, and the patient's history of seizure frequency, density, and clustering.  |  Semprino M, Fasulo L, Fortini S, Martorell Molina CI, González L, Ramos PA, Martínez C, Caraballo R. Epilepsy Behav. Thirty-five studies met inclusion criteria, including 13 080 epilepsy patients and 3941 patients with DRE. People withrefractory epilepsy may have trouble at work or school. The incidence of refractory epilepsy remains high despite the influx of many new antiepileptic drugs (AEDs) over the past 10 years. Animal Model Exp Med. The value of intra-operative electrographic biomarkers for tailoring during epilepsy surgery: from group-level to patient-level analysis. BMB Rep. 2020 Apr;53(4):234-239. doi: 10.5483/BMBRep.2020.53.4.002. 2 Overall, it has been assumed that JME responds well to AEDs. Demuru M, Kalitzin S, Zweiphenning W, van Blooijs D, Van't Klooster M, Van Eijsden P, Leijten F, Zijlmans M; RESPect Group. Sci Rep. 2020 Sep 4;10(1):14654. doi: 10.1038/s41598-020-71359-2. 2005 Jun;46(6):858-77. doi: 10.1111/j.1528-1167.2005.54904.x. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Refractory epilepsy can have a big effect on your life. The pooled prevalence proportion of DRE among epilepsy patients was 0.30 (95% confidence interval [CI] 0.19-0.42), and the pooled incidence proportion was 0.15 (95% CI 0.11-0.19). Active Epilepsy a. USA.gov. The definition of DRE varied widely across studies, with only 12% meeting the requirements of the ILAE definition. Low-frequency Stimulation Decreases Hyperexcitability Through Adenosine A1 Receptors in the Hippocampus of Kindled Rats. Asadi-Pooya AA, Stewart GR, Abrams DJ, Sharan A. Get the latest research from NIH: https://www.nih.gov/coronavirus. Refractory epilepsy: a clinically oriented review. Please enable it to take advantage of the complete set of features! Epilepsy Behav Rep. 2020 Sep 2;14:100390. doi: 10.1016/j.ebr.2020.100390. Risk factors for drug-resistant epilepsy: A systematic review and meta-analysis. 1. Epub 2020 May 1. doi: 10.1097/MD.0000000000016402. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Since individuals with refractory epilepsy do not share a common reason for their treatment resistance, the use of targeted drug therapies may be our best option for improving treatment outcomes in this patient population. They may also have injuriesthat result from their seizures. HHS Epub 2014 May 13. Epilepsia Open. NLM Int J Mol Sci. Pharmacogeneticists are currently attempting to understand the genetic basis of refractory epilepsy so that they can identify subgroups of patients who share a common genetic background and then target drug therapies to meet their specific needs. Vaughan KA, Lopez Ramos C, Buch VP, Mekary RA, Amundson JR, Shah M, Rattani A, Dewan MC, Park KB. J Neurosurg. More data based on the ILAE definition from well-designed epidemiologic studies are needed to generate accurate and reliable results. Results: Epub 2006 Mar 10. 1 This is about 3.4 million people with epilepsy nationwide: 3 million adults and 470,000 children. Epub 2018 Oct 2. 2018 Nov;88:176-180. doi: 10.1016/j.yebeh.2018.09.025. This is about 3.4 million people with epilepsy nationwide: 3 million adults and 470,000 children.Find the prevalence estimates for your state in the data table below. , is more common than most people might Think Regulates Kainic Acid-Induced seizure Neuronal... 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