titanocene dichloride
Decomposes in moist air and in water to form HCl . Six new titanocene compounds have been isolated and characterized. PATIENTS AND METHODS Twenty patients with a median age of 58 years received 83 courses of TD. Titanocene dichloride (National Toxicology Program, 1991) administered by gavage resulted in acute ulceration in the pyloric region of the stomach and diffuse foveolar epithelial necrosis. Abstract. Titanocene dichloride is known to be a potential anticancer drug since the late 1970s. The line widths of the proton magnetic resonance absorption spectra and the spin-lattice relaxation times for polycrystalline samples of ferrocene, ruthenocene, and titanocene dichloride were measured as functions of temperature, and are interpreted in terms of reorientation of the cyclopentadienyl rings about their fivefold axes. cyclopentadienyl group. After initial clinical trials against breast and renal-cell cancer were performed with this compound, the search for improved derivatives started. Despite extensive testing of titanocene dichloride which culminated in phase I and II clinical trials, further trials have been abandoned. PURPOSE To determine the maximum-tolerated dose (MTD) and the dose-limiting toxicities (DLTs) of a weekly schedule of titanocene dichloride (TD) and to define the pharmacokinetics of titanium in plasma and urine. Notes. Titanocene dichloride (TDC) is a red colored solid organometallic compound prepared from titanium tetrachloride. Under ambient conditions, the catalytic and electrocatalytic syntheses of ammonia from nitrogen and various proton sources including wet tetrahydrofuran (THF) and the protic solvents methanol and water were performed using titanocene dichloride ((η5-C5H5)2TiCl2, commonly abbreviated to CP2TiCl2) in a two-electrode cell containing 1.0 M LiCl as the electrolyte. NTP Toxicology and Carcinogenesis Studies of Titanocene Dichloride (CAS No. （2） Titanocene Dichloride improves stereo regularity due to the effect of. Name matches: cp2ticl2 bis (cyclopentadienyl)titanium dichloride. A one-pot and template-free strategy for synthesizing hollow TiO 2 nanostructures (HTSs) is developed by using titanocene dichloride as a titanium source, acetone as a solvent, and ammonia as a basic source. (NTP, 1992). It is used to prepare titanocene pentasulfide, a precursor to unusual alloptropes of sulfur and also investigated as an anticancer drug. Chemsrc provides Titanocene dichloride(CAS#:1271-19-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Titanocene C induced cell cycle arrest at the G1/0-S interphase. moderate conditions. Titanocene dichloride is … These complexes are bis … Titanocene Dichloride highly acts on the unsaturated compounds and shows. mechanism by which it acts is not understood, but some conjecture that it might be due to its interactions with the protein transferrin. These compounds were synthesized from their silyl-substituted fulvene or cyclopentadiene precursors using Super Hydride (LiBEt3H) or n-BuLi, followed by transmetalation with titanium tetrachloride, to yield the corresponding titanocene dichloride derivatives. Titanocene dichloride is an organometallic compound and is widely used in organometallic and organic synthesis both as a reagent and as a catalyst. Air & Water Reactions Stable in dry air. Belongs to the Following Reactive Group (s) The cancerostatic activity of metal complexes can be tested on mice by injection of tumor cells and, 24 h later, the substance to be investigated. The deposits observed by SEM and characterized by EPMA … titanocene dichloride (TDC), a highly active chemotherapeutic agent, with pendant alkylammonium groups on one or both rings. Organic synthesis: Titanocene Dichloride is a useful reagent for a wide variety of synthetic transformations. Titanocene(III) chloride (Cp(2)TiCl) mediated radical induced allylation of aldimines for the preparation of homoallyl amines is described. Titanocene Dichloride and derivatives are used as hydrogenation catalyst for rubbers, like SBS and SEBS, to improve heat stability and resistance to ozone/oxidation. While DNA has been implicated as the major target related to anticancer activity, identification of the active species and mechanism of action has been poorly understood and hence the design of second generation titanocene derivatives has not been possible. Andreas Gansäuer. Catalytic, Highly Regio‐ and Chemoselective Generation of Radicals from Epoxides: Titanocene Dichloride as an Electron Transfer Catalyst in Transition Metal Catalyzed Radical Reactions. The radical was generated from the allyl bromide using Cp(2)TiCl as the radical source. Titanocene dichloride is used as an experimental cancer chemotherapeutic agent. The animals were divided into six treatment groups … Titanocene dichloride was synthesized on this basis and has shown potent anti-neoplastic activity in experimental animals. Stable. excellent effects as an active homogeneous hydrogenation catalyst under. The present invention is directed to a process for the preparation of the reagent dimethyl titanocene (Cp2Ti(CH3)2) from titanocene dichloride (Cp2TiCl2) and a methyl magnesium halide, in particular, methyl magnesium chloride (CH3MgCl). Cross-resistance to either cisplatin or oxoplatin, respectively, was low for titanocene C and absent for titanocene Y in variant HL-60 cell lines. These complexes are bis-[((1-methyl-3-diethylaminomethyl)indol-2-yl)methylcyclopentadienyl] titanium … Polymerization: Titanocene Dichloride can be used with polymethylaluminoxane as a catalyst for metallocene type olefin polymerizations [2]. Its rising demand can be attributed to its varied properties such as catalyzing activity in organic-inorganic chemical synthesis, electrical conductivity, and ability to be incorporated in plant growth hormones, among others. Titanocene dichloride is used to prepare titanocene pentasulfide. Earlier results have demonstrated that derivatives containing either cyclic or chiral alkylammonium groups had increased cytotoxic activities. 1271-19-8) in F344/N Rats (Gavage Studies) PMID 12637960; National Toxicology Program technical report series 1991 Sep; 399 (? ):1-182. It exists as a bright red solid that slowly hydrolyzes in air. The control of enantioselectivity and diastereoselectivity of these transformations is investigated by variation of the ligands of the metal complex. The passage of titaniun containing metabolites across the placenta into the embryonal compartment was investigated by analyzing the titanium content in embryos/fetuses at various intervals between 1 hr and 24 hr after treatment of pregnant mice with single doses of the antitumor agent titanocene dichloride (60 mg/kg) on days 10, 12, 14 or 16 of gestation. TITANOCENE DICHLORIDE is incompatible with strong oxidizers. It exists as a bright red solid that slowly hydrolyzes in air. Air & Moisture Sensitive. It shows antitumour activity and was the first non-platinum complex to undergo clinical trials as a chemotherapy drug. Production Methods Titanocene dichloride is produced by the reaction of titanium tetrachloride with cyclopentadienyl sodium. It may decompose on exposure to water. Individual Protection Measures, Such as Personal Protective Equipment Then, draw the chemical structure of interest in the box using the toolbar. To search by structure, left click in the box below to display the chemdraw toolbar. Incompatible with strong acids, strong oxidizing agents and hot water. Titanocene dichloride, [Ti(-C 5 H 5) 2 Cl 2], is the most widely studied metallocene compound as a cytotoxic anticancer agent, which means that it can selectively kill cancer cells, and was used in phase I and II clinical trials [6–13]. Biopsy material from a native human ovarian carcinoma was expanded and transplanted into 96 nude mice. Media in category "Titanocene dichloride" The following 7 files are in this category, out of 7 total. Alterations in gene expression of NCI-H526 SCLC cells induced by titanocene C were investigated using genome-wide expression arrays. The serum levels of aldosterone , progesterone and catecholamines were not influenced by treatment with titanocene dichloride. Used as an anticancer drug. ABSTRACT The use of titanocene-dichloride (Cp2TiC12) as a metalorganic precursor for Tic coating provides layers of very different quality according to its temperature of vaporization in a cold wall CVD reactor. Structure, properties, spectra, suppliers and links for: Titanocene dichloride. These compounds were synthesised from their fulvene precursors using Super Hydride (LiBEt3H) followed by transmetallation with titanium tetrachloride to yield the corresponding titanocene dichloride derivatives. General Description Red to red-orange crystals. Titanocene dichloride is the organotitanium compound with the formula (η 5-C 5 H 5) 2 TiCl 2, commonly abbreviated as Cp 2 TiCl 2. Articles of Titanocene dichloride … Titanocene Dichloride can also be used with polymethylaluminoxane as a catalyst for metallocene type olefin polymerizations. It is existed as a bright red solid, forming acicular crystals when crystallized from toluene. We have examined the in vitro activity of titanocene dichloride in two pairs of platinum-sensitive and resistant human ovarian carcinoma cell lines, A2780/2780CP and CH1/CH1cisR, and in mutated p53- and bcl-2-transfected clones of A2780 cells. Titanocene dichloride is the organotitanium compound with the formula ( η 5 -C 5 H 5) 2 TiCl 2, commonly abbreviated as Cp 2 TiCl 2. Keep tightly closed in a dry, well-ventilated place. The new cytostatics titanocene dichloride and vinorelbine were compared to cisplatin and paclitaxel using a human ovarian cancer xenografts model. This metallocene is a common reagent in organometallic and organic synthesis. 01/01/1998 - "Titanocene dichloride could be an active chemotherapeutic drug in women with ovarian carcinoma not responding to standard therapies.01/01/1999 - "Titanocene dichloride was again significantly active in the KTCTL-1M carcinoma xenograft and caused relative growth reductions by 50-65%.01/01/1989 - "In 10 of these 14 carcinomas, titanocene dichloride effected growth suppression … Titanocene dichloride induced 5-6 fold increases in serum cortisol concentration of pregnant as well as of non-pregnant mice within 1-2 hr after substance application. Six new titanocene compounds have been isolated and characterised. Synonym: Cp 2 TiCl 2, Di(cyclopentadienyl)titanium(IV) dichloride, Titanocene dichloride Empirical Formula (Hill Notation): C 10 H 10 Cl 2 Ti Molecular Weight: 248.96 Particularly, lipophilic titanocene dichloride derivatives derived from fulveneswere synthesised in structural diversity and this led to the development of bis[(p-methoxybenzyl)cyclopentadienyl]titanium(IV) dichloride, which became better known in the literature un… Titanocene dichloride is the organotitanium compound with the formula (η5-C5H5)2TiCl2, commonly abbreviated as Cp2TiCl2. The generation and addition reactions of metal bound radicals derived from normal and meso epoxides by electron transfer from titanocene ( III) reagents is described. This metallocene is a common reagent in organometallic and organic synthesis.
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